highly efficient multicomponent biginelli’s synthesis of 3,4-dihydropyrimidin-2(1h)-ones catalyzed by al-mcm-41 under solvent-free conditions

in this study, an efficient and green process for the synthesis of dihydropyrimidin-2(1h)-ones from aromatic benzaldehydes, ethyl acetoacetate and urea using al-mcm-41 as heterogeneous catalyst and microreactor under solvent-free conditions has been developed. the advantages of this method are easy work-up procedure, regeneration of the catalyst, clean and neutral reaction conditions.